Nasal delivery as a strategy for the prevention and treatment of COVID-19
Introduction The upper respiratory tract is a major route of infection for COVID-19 and other
respiratory diseases. Thus, it appears logical to exploit the nose as administration site to …
respiratory diseases. Thus, it appears logical to exploit the nose as administration site to …
[HTML][HTML] Harvesting phosphorus-containing moieties for their antibacterial effects
M Voráčová, M Zore, J Yli-Kauhaluoma… - Bioorganic & Medicinal …, 2023 - Elsevier
Clinically manifested resistance of bacteria to antibiotics has emerged as a global threat to
society and there is an urgent need for the development of novel classes of antibacterial …
society and there is an urgent need for the development of novel classes of antibacterial …
Retrospective study and outcome of 307 cats with feline infectious peritonitis treated with legally sourced veterinary compounded preparations of remdesivir and GS …
SS Taylor, S Coggins, EN Barker… - Journal of feline …, 2023 - journals.sagepub.com
Objectives Feline infectious peritonitis (FIP) is a serious disease that arises due to feline
coronavirus infection. The nucleoside analogues remdesivir and GS-441524 can be …
coronavirus infection. The nucleoside analogues remdesivir and GS-441524 can be …
Expert consensus: main risk factors for poor prognosis in COVID-19 and the implications for targeted measures against SARS-CoV-2
FJ Candel, P Barreiro, M Salavert, A Cabello… - Viruses, 2023 - mdpi.com
The clinical evolution of patients infected with the Severe Acute Respiratory Coronavirus
type 2 (SARS-CoV-2) depends on the complex interplay between viral and host factors. The …
type 2 (SARS-CoV-2) depends on the complex interplay between viral and host factors. The …
Real life experience on the use of Remdesivir in patients admitted to COVID-19 in two referral Italian hospital: a propensity score matched analysis
N Veronese, F Di Gennaro, L Frallonardo… - Scientific Reports, 2024 - nature.com
Remdesivir (RDV) was the first Food and Drug Administration (FDA)-approved medication
for COVID-19, with discordant data on efficacy in reducing mortality risk and disease …
for COVID-19, with discordant data on efficacy in reducing mortality risk and disease …
Use of Remdesivir in Patients Hospitalized for COVID-19 Pneumonia: Effect on the Hypoxic and Inflammatory State
A Libra, N Ciancio, G Sambataro, E Sciacca… - Viruses, 2023 - mdpi.com
Remdesivir is one of the most attractive options for patients with hypoxemic respiratory
failure due to coronavirus disease 2019 (COVID-19). The aim of our study was to evaluate …
failure due to coronavirus disease 2019 (COVID-19). The aim of our study was to evaluate …
A community effort in SARS‐CoV‐2 drug discovery
The COVID‐19 pandemic continues to pose a substantial threat to human lives and is likely
to do so for years to come. Despite the availability of vaccines, searching for efficient small …
to do so for years to come. Despite the availability of vaccines, searching for efficient small …
Theory and Practice of Glucocorticoids in COVID-19: Getting to the Heart of the Matter—A Critical Review and Viewpoints
Prolonged, low-dose glucocorticoids (GCs) have shown the highest efficacy among
pharmacological and non-pharmacological treatments for COVID-19. Despite the World …
pharmacological and non-pharmacological treatments for COVID-19. Despite the World …
[HTML][HTML] Comparative effectiveness of combination therapy with nirmatrelvir–ritonavir and remdesivir versus monotherapy with remdesivir or nirmatrelvir–ritonavir in …
Summary Background Remdesivir (Veklury, Gilead Sciences, Foster City, CA, USA) and
nirmatrelvir–ritonavir (Paxlovid, Pfizer, New York, NY, USA) were reported to improve the …
nirmatrelvir–ritonavir (Paxlovid, Pfizer, New York, NY, USA) were reported to improve the …
A guide for the synthesis of key nucleoside scaffolds in drug discovery
DG Rajapaksha, S Mondal, JW Wang… - Medicinal Chemistry …, 2023 - Springer
This review aims to provide an overview of the synthetic strategies employed for generating
modifications within the sugar backbone of nucleoside analogs. We have focused our …
modifications within the sugar backbone of nucleoside analogs. We have focused our …