Effective population size (N e) is a key parameter in population genetics. It has important
applications in evolutionary biology, conservation genetics and plant and animal breeding …

We will soon have complete genome sequences from thousands of species, as well as from
many individuals within species. This coming explosion of information will transform our …

Infectious diseases are among the strongest selective pressures driving human evolution,.
This includes the single greatest mortality event in recorded history, the first outbreak of the …

Progress in defining genomic fitness landscapes in cancer, especially those defined by copy
number alterations (CNAs), has been impeded by lack of time-series single-cell sampling of …

Natural history collections provide an immense record of biodiversity on Earth. These
repositories have traditionally been used to address fundamental questions in …

Population census size (NC) and effective population sizes (N e) are two crucial parameters
that influence population viability, wildlife management decisions, and conservation …

The transformation of wild animals into domestic ones available for human nutrition was a
key prerequisite for modern human societies. However, no other domestic species has had …

Ecologists and evolutionary biologists are well aware that natural and sexual selection do
not operate on traits in isolation, but instead act on combinations of traits. This long …

In rapidly adapting asexual populations, including many microbial pathogens and viruses,
numerous mutant lineages often compete for dominance within the population,,,–. These …

Most current methods for detecting natural selection from DNA sequence data are limited in
that they are either based on summary statistics or a composite likelihood, and as a …