Cancer and Alzheimer's disease inverse relationship: An age-associated diverging derailment of shared pathways

C Lanni, M Masi, M Racchi, S Govoni - Molecular Psychiatry, 2021 - nature.com
Several epidemiological studies show an inverse association between cancer and
Alzheimer's disease (AD). It is debated whether this association is the consequence of …

[HTML][HTML] Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer

Z Hang, T Lei, Z Zeng, S Cai, W Bi, H Du - Biomedicine & Pharmacotherapy, 2022 - Elsevier
An increasing number of epidemiological studies have shown that there is a significant
inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) …

Inverse correlation between Alzheimer's disease and cancer: short overview

A Zabłocka, W Kazana, M Sochocka… - Molecular …, 2021 - Springer
The negative association between Alzheimer's disease (AD) and cancer suggests that
susceptibility to one disease may protect against the other. When biological mechanisms of …

[PDF][PDF] Identification of peripheral blood immune infiltration signatures and construction of monocyte-associated signatures in ovarian cancer and Alzheimer's disease …

S Zhao, B Ye, H Chi, C Cheng, J Liu - Heliyon, 2023 - cell.com
Background Ovarian cancer (OC) is a common tumor of the female reproductive system,
while Alzheimer's disease (AD) is a prevalent neurodegenerative disease that primarily …

Cobalt induces neurodegenerative damages through Pin1 inactivation in mice and human neuroglioma cells

F Zheng, Y Li, F Zhang, Y Sun, C Zheng, Z Luo… - Journal of Hazardous …, 2021 - Elsevier
Cobalt is a hazardous material that has harmful effects on neurotoxicity. Excessive exposure
to cobalt or inactivation of the unique proline isomerase Pin1 contributes to age-dependent …

Transfer of tumor-bearing mice intestinal flora can ameliorate cognition in Alzheimer's disease mice

Z Hang, S Cai, T Lei, X Zhang, Z Xiao… - Journal of …, 2022 - content.iospress.com
Background: Fecal microbiota transplant (FMT) is a potential treatment approach for many
diseases. Alzheimer's disease (AD) and cancer have been proven to have a specific …

Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer's phenotypes without blocking peripheral T cell IL-2 response

NR Stallings, MA O'Neal, J Hu, ZJ Shen… - Alzheimer's Research & …, 2023 - Springer
Abstract Background Current treatments for Alzheimer's disease (AD) have largely failed to
yield significant therapeutic benefits. Novel approaches are desperately needed to help …

Comorbidity among inpatients with dementia: a preliminary cross-sectional study in West China

X Xiao, S Xiang, Q Xu, J Li, J Xiao, Y Si - Aging Clinical and Experimental …, 2023 - Springer
Objective To investigate comorbidities among hospitalized patients with dementia. Method
Data were extracted from the discharge records in our hospital. Comorbidities based on ICD …

Dual action of dipyridothiazine and quinobenzothiazine derivatives—Anticancer and cholinesterase-inhibiting activity

J Jończyk, J Godyń, E Stawarska, B Morak-Młodawska… - Molecules, 2020 - mdpi.com
The inverse correlation observed between Alzheimer's disease (AD) and cancer has
prompted us to look for cholinesterase-inhibiting activity in phenothiazine derivatives that …

Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation …

W Xia, Z Gao, X Jiang, L Jiang, Y Qin, D Zhang, P Tian… - Plos one, 2022 - journals.plos.org
Increasing evidence from epidemiological studies indicate that Alzheimer's disease (AD)
has a negative relationship with the incidence of cancers. Whether the Alzheimer's genetic …