B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

Over the recent years the wider availability and application of state-of-the-art immunological
technologies greatly advanced the insight into the mechanisms that play an important role in …

Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted
at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy …

Axial spondyloarthritis (axial-SpA) is a multifactorial disease characterized by inflammation
in sacroiliac joints and spine, bone reabsorption, and aberrant bone deposition, which may …

Abstract Purpose of Review To commemorate the 50th anniversary of the groundbreaking
discovery of a remarkably strong association between HLA-B* 27 and ankylosing spondylitis …

INTRODUCTION: Viral infections have been associated with the progression of
atherosclerosis and CD8+ T-cells directed against common viruses, such as influenza …

HLA-B* 27 was one of the first HLA alleles associated with an autoimmune disease, ie, axial
spondyloarthritis (axSpA) and acute anterior uveitis (B27AAU), which cause joint and eye …

The relationships among immune cells, metabolites, and AS events were analyzed via
Mendelian randomization (MR), and potential immune cells and metabolites were identified …

HLA-B* 27 confers a strong risk of developing spondyloarthritis (SpA), which includes axial
SpA with or without peripheral arthritis, enthesitis, acute anterior uveitis and gastrointestinal …

The immune repertoire (IR) is a term that defines the combined unique genetic
rearrangements of antigen receptors expressed by B and T lymphocytes. The IR determines …