Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …

An increasing number of commonly prescribed drugs are known to interfere with
mitochondrial function, which is associated with almost half of all Food and Drug …

Background: Dietary polyphenols help to prevent cardiovascular diseases, and interactions
between polyphenols and gut microbiota are known to exist. In this study, we speculated that …

Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but
also contributes to the high morbidity and mortality rates of cardiovascular diseases …

Abstract Cytochrome P4502J2 (CYP2J2) metabolizes arachidonic acid (AA) to
cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug …

Metabolic activation of drugs by cytochrome P450 enzymes (P450) to chemically reactive
electrophiles is commonly regarded as a key molecular-initiating event underpinning …

Infigratinib (INF) is a fibroblast growth factor receptor inhibitor that was recently United States
Food and Drug Administration-approved for the treatment of advanced or metastatic …

Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans.
It has previously been demonstrated that amiodarone and its metabolite …

Cardiac and extra-cardiac side effects of common antiarrhythmic agents might be related to
drug-induced mitochondrial dysfunction. Supratherapeutic doses of amiodarone have been …

Covalent tyrosine kinase inhibitors (TKIs) ibrutinib and osimertinib are associated with
cardiac arrhythmia. The interactions between these TKIs with CYP2J2 that is highly …