The process of neurogenesis includes neural stem cell proliferation, fate specification,
young neuron migration, neuronal maturation, and functional integration into existing …

Cancer cells proliferate, differentiate and migrate by repurposing physiological signalling
mechanisms. In particular, altered calcium signalling is emerging as one of the most …

The proximal tubule has a remarkable capacity for repair after acute injury, but the cellular
lineage and molecular mechanisms underlying this repair response are incompletely …

The histone methyltransferase EZH2 is a central epigenetic regulator of cell survival,
proliferation, and cancer stem cell (CSC) function. EZH2 expression is increased in various …

Long noncoding RNAs (lncRNAs) are key regulators of diverse biological processes such as
transcriptional regulation, cell growth and differentiation. Previous studies have …

Introduction: Stem cells are cells with the ability to grow and differentiate into more than 200
cell types. Sources of data: We review here the characteristics and potential of human …

EZH2 plays an important role in stem cell renewal and maintenance by inducing gene
silencing via its histone methyltransferase activity. Previously, we showed that EZH2 …

Differentiation of osteoblasts from mesenchymal stem cells (MSCs) is an integral part of
bone development and homeostasis, and may when improperly regulated cause disease …

Using a mouse model of ependymoma—a chemoresistant brain tumor—we combined
multicell high-throughput screening (HTS), kinome-wide binding assays, and in vivo efficacy …

The coordinated development of the nervous system requires fidelity in the expression of
specific genes determining the different neural cell phenotypes. Stem cell fate decisions …