Myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) are natural compounds involved in
many biological pathways. Since the discovery of their involvement in endocrine signal …

Poly Cystic Ovarian Syndrome (PCOS) is one of the most common metabolic and
reproductive disorders among women of reproductive age. Women suffering from PCOS …

Zinc is an essential microelement that plays many important functions in the body. It is
crucial for the regulation of cell growth, hormone release, immunological response and …

Polycystic ovary syndrome (PCOS) is a heterogenous disorder characterized by chronic
ovulation dysfunction and hyperandrogenism. It is considered the most common …

Childhood obesity has become a major health concern in recent decades, especially with
regard to metabolic abnormalities that impart a high risk for future cardiovascular disease …

Metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes.
Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its …

Metformin is the most commonly prescribed drug for type 2 diabetes (T2DM). Retrospective
studies show that metformin is associated with decreased cancer risk. This historical …

Polycystic ovary syndrome (PCOS) affects 5%–10% of women in reproductive age, and it is
the most common cause of infertility due to ovarian dysfunction and menstrual irregularity …

Insulin resistance (IR) plays a pivotal role in PCOS. Insulin-sensitizer agents such as
metformin and inositols have been shown to improve the endocrine and metabolic aspects …

Metformin (MET), the most commonly used insulin sensitizer, is the reference off-label drug
for the treatment of polycystic ovary syndrome (PCOS), worldwide. However, its use may be …