Dexmedetomidine (DEX) is a highly selective α2 receptor agonist that is routinely used in
the clinic for sedation and anesthesia. Recently, an increasing number of studies have …

Estradiol exerts neuroprotective actions that are mediated by the regulation of a variety of
signaling pathways and homeostatic molecules. Among these is neuroglobin, which is …

Background Diabetic cutaneous ulcers (DCU) are a complication of diabetes with diabetic
foot ulcers being the most common, and the wounds are difficult to heal, increasing the risk …

Neuroglobin, which is a heme protein from the globin family that is predominantly expressed
in nervous tissue, can promote a neuronal survivor. However, the molecular mechanisms …

Neuroglobin (Ngb), the third member of the globin family, was discovered in human and
murine brains in 2000. This monomeric globin is structurally similar to myoglobin (Mb) and …

Earlier work has shown that siRNA-mediated reduction of the SUPT4H or SUPT5H proteins,
which interact to form the DSIF complex and facilitate transcript elongation by RNA …

Retinal neurodegeneration affects an increasing number of people worldwide causing
vision impairments and blindness, reducing quality of life, and generating a great economic …

The sequence and structure of human cytochrome c (hCyt c) exhibit evolutionary
conservations, with only a limited number of naturally occurring mutations in humans …

The functional integrity of the central nervous system relies on complex mechanisms in
which the mitochondria are crucial actors because of their involvement in a multitude of …

Cerebral ischemia/reperfusion (I/R) injury remains a grievous health threat, and herein
effective therapy is urgently needed. This study explored the protection of neuroglobin (Ngb) …