An emphasis on the interaction of signaling pathways highlights the role of miRNAs in the etiology and treatment resistance of gastric cancer

D Fathi, MS Elballal, AE Elesawy, AI Abulsoud… - Life Sciences, 2023 - Elsevier
Gastric cancer (GC) is 4th in incidence and mortality rates globally. Several genetic and
epigenetic factors, including microRNAs (miRNAs), affect its initiation and progression …

The interplay of signaling pathways and miRNAs in the pathogenesis and targeted therapy of esophageal cancer

AS Doghish, AA El-Husseiny… - … -Research and Practice, 2023 - Elsevier
Globally, esophageal cancer (EC) is the 6th leading cause of cancer-related deaths and the
second deadliest gastrointestinal cancer. Multiple genetic and epigenetic factors, such as …

Targeting epigenetics: A novel promise for Alzheimer's disease treatment

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives

LA Bravo-Vázquez, A Méndez-García… - … in Bioengineering and …, 2023 - frontiersin.org
MicroRNAs (miRNAs) are short (18–25 nt), non-coding, widely conserved RNA molecules
responsible for regulating gene expression via sequence-specific post-transcriptional …

Targeting gastric cancer stem cells to enhance treatment response

X Rao, C Zhang, H Luo, J Zhang, Z Zhuang, Z Liang… - Cells, 2022 - mdpi.com
Gastric cancer (GC) was the fourth deadliest cancer in the world in 2020, and about 770,000
people died from GC that year. The death of patients with GC is mainly caused by the …

Recent advances on high-efficiency of microRNAs in different types of lung cancer: a comprehensive review

MS Sadeghi, M Lotfi, N Soltani, E Farmani… - Cancer Cell …, 2023 - Springer
Carcinoma of the lung is among the most common types of cancer globally. Concerning its
histology, it is categorized as a non-small cell carcinoma (NSCLC) and a small cell cancer …

Aptamer functionalized nucleic acid nano drug for targeted synergistic therapy for colon cancer

L Zhu, J Yuhan, H Yu, B Zhang, L Zhu, X He… - Journal of …, 2023 - Springer
Due to its complicated pathophysiology, propensity for metastasis, and poor prognosis,
colon cancer is challenging to treat and must be managed with a combination of therapy …

Self-assembled pH-responsive DNA nanosponges for targeted co-delivery of doxorubicin and capsaicin for colorectal cancer therapy

C Asakiya, Y Zhang, L Zhu, M Ackah, S Tavakoli… - Biochemical …, 2023 - Elsevier
DNA nanostructures have been engineered into various delivery systems for anti-cancer
chemotherapy. However, these nanostructures are hindered in their therapeutic applications …

MiRNAs as potential therapeutic targets and biomarkers for non-traumatic intracerebral hemorrhage

I Gareev, O Beylerli, B Zhao - Biomarker Research, 2024 - Springer
Non-traumatic intracerebral hemorrhage (ICH) is the most common type of hemorrhagic
stroke, most often occurring between the ages of 45 and 60. Hypertension is most often the …

Non-coding RNAs in skin cancers: Biological roles and molecular mechanisms

F Liu, S Li - Frontiers in Pharmacology, 2022 - frontiersin.org
Cutaneous malignancies, including basal cell carcinoma, cutaneous squamous cell
carcinoma, and cutaneous melanoma, are common human tumors. The incidence of …