Recombinant interferon‐α (IFN‐α) was approved by regulatory agencies in many countries
in 1986. As the first biotherapeutic approved, IFN‐α paved the way for the development of …

Maternal recognition of pregnancy refers to the requirement for the conceptus (embryo and
its associated extra-embryonic membranes) to produce a hormone that acts on the uterus …

This review integrates established and new information on the role of progesterone,
interferon tau (IFNT), and prostaglandins in uterine biology of ruminants. Establishment of …

The majority of pregnancy loss in ruminants occurs during the first three weeks after
conception, particularly during the period of conceptus elongation that occurs prior to …

Type I and/or type II interferons (IFNs) are important in establishing uterine receptivity to
implantation in mammals. Gene expression effected by IFNs may be induced, stimulated or …

Active demethylation of cytosine residues in the sperm genome before forming a functional
zygotic nucleus is thought to be an important function of the oocyte cytoplasm for …

Viruses need to multiply extensively in the infected host in order to ensure transmission to
new hosts and survival as a population. This is a formidable task, given the powerful innate …

The establishment of pregnancy in ruminants occurs during the peri-implantation period and
involves the suppression of the endometrial luteolytic mechanism to maintain progesterone …

The interferon system provides a powerful and universal intracellular defense mechanism
against viruses. Knockout mice defective in IFN signaling quickly succumb to all kinds of …

The sudden emergence of severe acute respiratory syndrome (SARS) has boosted research
on innate immune responses to coronaviruses. It is now well established that the causative …