Runs of homozygosity: current knowledge and applications in livestock

E Peripolli, DP Munari, M Silva, ALF Lima… - Animal …, 2017 - Wiley Online Library
This review presents a broader approach to the implementation and study of runs of
homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH …

Genomics advances the study of inbreeding depression in the wild

M Kardos, HR Taylor, H Ellegren… - Evolutionary …, 2016 - Wiley Online Library
Inbreeding depression (reduced fitness of individuals with related parents) has long been a
major focus of ecology, evolution, and conservation biology. Despite decades of research …

How to study runs of homozygosity using PLINK? A guide for analyzing medium density SNP data in livestock and pet species

R Meyermans, W Gorssen, N Buys, S Janssens - BMC genomics, 2020 - Springer
Background PLINK is probably the most used program for analyzing SNP genotypes and
runs of homozygosity (ROH), both in human and in animal populations. The last decade …

Inbreeding and runs of homozygosity before and after genomic selection in North American Holstein cattle

M Forutan, S Ansari Mahyari, C Baes, N Melzer… - BMC genomics, 2018 - Springer
Background While autozygosity as a consequence of selection is well understood, there is
limited information on the ability of different methods to measure true inbreeding. In the …

Selection signatures in livestock genome: A review of concepts, approaches and applications

KA Saravanan, M Panigrahi, H Kumar, B Bhushan… - Livestock Science, 2020 - Elsevier
Livestock populations have been consistently improving in terms of performance and
productivity by selective breeding over the centuries. These selection strategies are …

A publicly available repository of ROH islands reveals signatures of selection in different livestock and pet species

W Gorssen, R Meyermans, S Janssens… - Genetics Selection …, 2021 - Springer
Background Runs of homozygosity (ROH) have become the state-of-the-art method for
analysis of inbreeding in animal populations. Moreover, ROH are suited to detect signatures …

From molecules to populations: appreciating and estimating recombination rate variation

JV Peñalba, JBW Wolf - Nature Reviews Genetics, 2020 - nature.com
Recombination is a central biological process with implications for many areas in the life
sciences. Yet we are only beginning to appreciate variation in the recombination rate along …

Genomic insights into the conservation status of the world's last remaining Sumatran rhinoceros populations

J Von Seth, N Dussex, D Díez-del-Molino… - Nature …, 2021 - nature.com
Small populations are often exposed to high inbreeding and mutational load that can
increase the risk of extinction. The Sumatran rhinoceros was widespread in Southeast Asia …

Population dynamics of Baltic herring since the Viking Age revealed by ancient DNA and genomics

LM Atmore, L Martínez-García… - Proceedings of the …, 2022 - National Acad Sciences
The world's oceans are currently facing major stressors in the form of overexploitation and
anthropogenic climate change. The Baltic Sea was home to the first “industrial” fishery∼ 800 …

Genetic architecture and lifetime dynamics of inbreeding depression in a wild mammal

MA Stoffel, SE Johnston, JG Pilkington… - Nature …, 2021 - nature.com
Inbreeding depression is ubiquitous, but we still know little about its genetic architecture and
precise effects in wild populations. Here, we combine long-term life-history data with 417 K …