Polypharmacology describes the activity of compounds at multiple targets. Current research
focuses on two aspects of polypharmacology:(1) unintended polypharmacology can lead to …

Abstract 'Drug‐likeness', a qualitative property of chemicals assigned by experts committee
vote, is widely integrated into the early stages of lead and drug discovery. Its conceptual …

P-glycoprotein (Pgp or ABCB1) is an ABC transporter protein involved in intestinal
absorption, drug metabolism, and brain penetration, and its inhibition can seriously alter a …

Abstract Systems pharmacology is an emergent area that studies drug action across multiple
scales of complexity, from molecular and cellular to tissue and organism levels. There is a …

Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and
Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the …

The cardiotoxicity associated with des-ethyl-dexfenfluramine (norDF) and related agonists of
the serotonin receptor 2B (5-HT2B) has solidified the receptor's place as an “antitarget” in …

Background and Purpose Chemogenomics focuses on the discovery of new connections
between chemical and biological space leading to the discovery of new protein targets and …

hERG potassium channels have a critical role in the normal electrical activity of the heart.
The block of hERG channels can cause the drug-induced form of long QT syndrome, a …

Assessment of drug candidate's potential to inhibit cytochrome P450 (CYP) enzymes
remains crucial in pharmaceutical drug discovery and development. Both direct and time …

Background: Since the last few decades, the healthcare sector is facing the problem of the
development of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis …