Many cancers have long been thought to primarily metabolize glucose for energy production—
a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the …

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia
are important factors in aging. Insulin/insulin-like growth factor 1 (IGF-1) signaling molecules …

AMP-activated protein kinase (AMPK) is an evolutionarily conserved energy sensor
important for cell growth, proliferation, survival, and metabolic regulation. Active AMPK …

High-grade gliomas, glioblastomas (GB), are refractory to conventional treatment combining
surgery, chemotherapy, mainly temozolomide, and radiotherapy. This highlights an urgent …

This chapter focuses on the role of AMPK as a stress-response molecule with an emphasis
on its duplex implication in carcinogenesis and cancer drug resistance. AMPK is closely …

Population studies have shown that treatment with the antidiabetic biguanide metformin
significantly reduced cancer risk. In our animal studies, metformin delayed the onset of …

In eukaryotic cells, AMP-activated protein kinase (AMPK) generally promotes catabolic
pathways that produce ATP and at the same time inhibits anabolic pathways involved in …

BH3 mimetics, including the BCL2/BCLXL/BCLw inhibitor navitoclax and MCL1 inhibitors
S64315 and tapotoclax, have undergone clinical testing for a variety of neoplasms. Because …

Impaired epithelial barrier function plays a crucial role in the pathogenesis of inflammatory
bowel disease. Elevated levels of the pro-inflammatory cytokine, interferon-γ (IFNγ), are …

Background Obesity alters adipose tissue metabolic and endocrine functioning, leading to
an increased adiposity and release of pro-inflammatory cytokines. Various phytochemicals …