The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

The presence of introns in both protein‐coding and noncoding RNA transcripts is a
fascinating phenomenon. It seems counterintuitive that an organism would devote precious …

Mature tRNAs are generated by multiple post-transcriptional processing steps, which can
include intron removal. Recently, we discovered a new class of circular non-coding RNAs in …

The splicing of tRNA introns is a critical step in pre-tRNA maturation. In archaea and
eukaryotes, tRNA intron removal is catalyzed by the tRNA splicing endonuclease (TSEN) …

The splicing of transfer RNA (tRNA) introns is a critical step of tRNA maturation, for intron‐
containing tRNAs. In eukaryotes, tRNA splicing is a multi‐step process that relies on several …

Eukaryotes share a conserved messenger RNA (mRNA) decay pathway in which bulk
mRNA is degraded by exoribonucleases. In addition, it has become clear that more …

Abstract The No-Go Decay (NGD) mRNA surveillance pathway degrades mRNAs containing
stacks of stalled ribosomes. Although an endoribonuclease has been proposed to initiate …

During tRNA maturation in yeast, aberrant pre-tRNAs are targeted for 3′–5′ degradation
by the nuclear surveillance pathway, and aberrant mature tRNAs are targeted for 5′–3 …

Rare, full-length circular intron RNAs distinct from lariats have been reported in several
species, but their biogenesis is not understood. We envisioned and tested a hypothesis for …

The Dxo1/Rai1/DXO family of decapping and exonuclease enzymes can catalyze the in vitro
removal of chemically diverse 5′ ends from RNA. Specifically, these enzymes act poorly on …