Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …

Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

Recent studies have profiled the innate immune signatures in patients infected with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and suggest that cellular …

Executive summary The past six decades have seen remarkable improvements in health
outcomes for people with cystic fibrosis, which was once a fatal disease of infants and young …

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear …

Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …

Alveolar type II (ATII) cells are a key structure of the distal lung epithelium, where they exert
their innate immune response and serve as progenitors of alveolar type I (ATI) cells …

The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells
to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key …