As people around the world regard 2020 as the year of COVID-19, the medical community
considers this year to be the second-best year, shared with the year 1996, with respect to the …

Background Hereditary angioedema (HAE) is a rare disease characterized by
unpredictable, potentially life-threatening attacks, resulting in significant physical and …

Hereditary Angioedema (HAE) is a rare and disabling disease for which early diagnosis and
effective therapy are critical. This revision and update of the global WAO/EAACI guideline on …

Background Hereditary angioedema is a rare genetic disease that leads to severe and
unpredictable swelling attacks. NTLA-2002 is an in vivo gene-editing therapy based on …

Background Hereditary angioedema is a rare and potentially life-threatening genetic
disease that is associated with kallikrein–kinin system dysregulation. Garadacimab …

Background Hereditary angioedema is characterized by recurrent and unpredictable
swellings that are disabling and potentially fatal. Selective inhibition of plasma prekallikrein …

Background: High blood cholesterol accelerates the progression of atherosclerosis, which is
an asymptomatic process lasting for decades. Rupture of atherosclerotic plaques induces …

The evolution in the knowledge of rare genetic diseases such as hereditary angioedema
(HAE) has increased at a parallel pace with the development of new molecular tools. The …

Bradykinin, a member of the kallikrein-kinin system (KKS), is associated with an
inflammatory response pathway with diverse vascular permeability functions, including …

Hereditary angioedema (HAE) is a rare disease that causes episodic attacks of
subcutaneous and submucosal edema, which can be painful, incapacitating, and potentially …