Biocatalysis harnesses enzymes to make valuable products. This green technology is used
in countless applications from bench scale to industrial production and allows practitioners …

Emerging computational tools promise to revolutionize protein engineering for biocatalytic
applications and accelerate the development timelines previously needed to optimize an …

Introduction In the field of bioconjugates, the focus on antibody–drug conjugates (ADCs)
with novel payloads beyond the traditional categories of potent cytotoxic agents is …

Enzyme biocatalysis is reshaping pharmaceutical synthesis, offering sustainable and
efficient pathways for drug discovery and production. This paradigm shift towards eco …

Antibiotic resistance is a major driver of morbidity and mortality worldwide, necessitating
alternatives. Due to their mechanism of action, bacteriophages, endolysins, and …

Therapeutic oligonucleotides are a powerful drug modality with the potential to treat many
diseases. The rapidly growing number of therapies that have been approved and that are in …

This review outlines the latest findings on bioconjugation using lipoic acid ligase A (LplA), a
key enzyme that allows the introduction of new functional groups into biomolecules. LplA …

Maleimide derivatives are privileged reagents for chemically modifying proteins through the
Michael addition reaction with cysteine due to their selectivity, operational simplicity, and …

The ability of Bacillus subtilis transglutaminase (bTG) to functionalize BSA has been
investigated using peptide mapping experiments. Interestingly, the conjugation was not …

This article presents bioconjugates combining nanoparticles (AGuIX) with nanobodies
(VHH) targeting Programmed Death-Ligand 1 (PD-L1, A12 VHH) and Cluster of …