X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at
epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating …

Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …

Summary The lncRNA Xist forms∼ 50 diffraction-limited foci to transcriptionally silence one
X chromosome. How this small number of RNA foci and interacting proteins regulate a much …

Low expression levels and stoichiometric imbalances of long noncoding RNAs (lncRNAs)
are often used as evidence for their probable lack of function or for limiting the scope of their …

Development is a complex process regulated both by genetic and epigenetic and
environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key …

Gastric cancer is a deadly disease and remains the third leading cause of cancer-related
death worldwide. The 5-year overall survival rate of patients with early-stage localized …

Chromosome-wide late replication is an enigmatic hallmark of the inactive X chromosome
(Xi). How it is established and what it represents remains obscure. By single-cell DNA …

Chromosome organization mediated by structural maintenance of chromosomes (SMC)
complexes is vital in many organisms. SMC complexes act as motors that extrude DNA …

In female eutherian mammals, dosage compensation of X-linked gene expression is
achieved during development through transcriptional silencing of one of the two X …