Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic
balance of fusion and fission of mitochondria determines their morphology and allows their …

Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …

The organization and mutual interactions between endoplasmic reticulum (ER) and
mitochondria modulate key aspects of cell pathophysiology. Several proteins have been …

The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …

The Mitofusin 2 protein (MFN2), encoded by the MFN2 gene, was first described for its role
in mediating mitochondrial fusion. However, MFN2 is now recognized to play additional …

In mammals, peroxisomes perform crucial functions in cellular metabolism, signalling and
viral defense which are essential to the health and viability of the organism. In order to …

Mutations in the GDAP1 gene cause Charcot–Marie–Tooth (CMT) neuropathy. GDAP1 is an
atypical glutathione S-transferase (GST) of the outer mitochondrial membrane and the …

Peripheral nerves have peculiar energetic requirements because of considerable length of
axons and therefore correct mitochondria functioning and distribution along nerves is …

By influencing Ca2+ homeostasis in spatially and architecturally distinct neuronal
compartments, the endoplasmic reticulum (ER) illustrates the notion that form and function …

Abstract Introduction Mutations in GDAP1 (Ganglioside-induced differentiation-associated
protein 1) gene are linked to Charcot-Marie-Tooth disease (CMT), a Heterogenous group of …