Measuring biological age using omics data
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …
related diseases and increase healthspan have suggested targeting the ageing process …
Genetics meets proteomics: perspectives for large population-based studies
Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …
complex processes influencing human biology. Proteins represent intermediate phenotypes …
Organ aging signatures in the plasma proteome track health and disease
Animal studies show aging varies between individuals as well as between organs within an
individual,,–, but whether this is true in humans and its effect on age-related diseases is …
individual,,–, but whether this is true in humans and its effect on age-related diseases is …
Proteomic signatures improve risk prediction for common and rare diseases
J Carrasco-Zanini, M Pietzner, J Davitte, P Surendran… - Nature medicine, 2024 - nature.com
For many diseases there are delays in diagnosis due to a lack of objective biomarkers for
disease onset. Here, in 41,931 individuals from the United Kingdom Biobank Pharma …
disease onset. Here, in 41,931 individuals from the United Kingdom Biobank Pharma …
Cohort profile update: the HUNT study, Norway
BO Åsvold, A Langhammer, TA Rehn… - International journal …, 2023 - academic.oup.com
The Trøndelag Health Study (the HUNT Study) is a population-based cohort study of the
adult population in Trøndelag County, Norway. It was previously called the Nord-Trøndelag …
adult population in Trøndelag County, Norway. It was previously called the Nord-Trøndelag …
Undulating changes in human plasma proteome profiles across the lifespan
Aging is a predominant risk factor for several chronic diseases that limit healthspan.
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …
Blood protein assessment of leading incident diseases and mortality in the UK Biobank
The circulating proteome offers insights into the biological pathways that underlie disease.
Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age …
Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age …
Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
Systems biology in cardiovascular disease: a multiomics approach
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …
new informatics approaches alongside conventional statistical methods. Systems theories …
Genomic atlas of the human plasma proteome
Although plasma proteins have important roles in biological processes and are the direct
targets of many drugs, the genetic factors that control inter-individual variation in plasma …
targets of many drugs, the genetic factors that control inter-individual variation in plasma …