The anti‐breast cancer therapeutic potential of 1, 2, 3‐triazole‐containing hybrids

J Song, S Zhang, B Zhang, J Ma - Archiv der Pharmazie, 2024 - Wiley Online Library
Breast cancer, as one of the most common invasive malignancies and the leading cause of
cancer‐related deaths in women globally, poses a significant challenge in the world health …

Organocatalytic [3+ 2] Cycloaddition reaction: synthesis of fully decorated sulfonyl-1, 2, 3-triazolyl pyrimidines as potent anticancer and EGFR inhibitors

JMR Velidandla, SK Koppula - Polycyclic Aromatic Compounds, 2024 - Taylor & Francis
A general strategy was developed for the synthesis of new fully decorated sulfonyl1, 2, 3-
triazolyl pyrimidines (6a–6j and 8a–8f) from 2-((6-methyl-2-(methylsulfonyl) pyrimidin-4-yl) …

One-pot synthesis, anticancer, EGFR and caspases assays of novel fused [1, 2, 3] triazolo-pyrrolo [2, 1-b] quinazolinones

N Udayasree, RB Haridasyam, R Palabindela… - Journal of Molecular …, 2025 - Elsevier
In this study, we designed and synthesized several novel fused [1, 2, 3] triazolo [4′, 5′: 3,
4] pyrrolo [2, 1-b] quinazolinone derivatives using a single [3+ 2] reaction cycloaddition …

Organocatalytic [3+ 2] Cycloaddition Reaction: Synthesis of Fully Decorated Sulfonyl 1, 2, 3‐Triazoles as Potent EGFR Targeting Anticancer Agents

V Reddy Dodlapati, T Madhukar Reddy… - …, 2023 - Wiley Online Library
A general strategy was developed for the synthesis of new fully decorated sulfonyl1, 2, 3‐
triazolyl imidazoles from β‐ketosulfones and several aryl sulfonyl azides using the …

Synthesis of [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine-1, 2, 3-triazoles as potent EGFR targeting anti-breast cancer agents

S Chirra, R Gondru, M Manne, M Azam… - Journal of Molecular …, 2024 - Elsevier
Synthetic chemists have organized easy and effective ways for perfect synthesis in response
to the requirement for scaffolds that are crucial for medical applications. A general strategy …

Synthesis and biological evaluation of pyrido[3,2,1-ij][1,2,3]triazolo[4,5-c] quinolinones: PEG-400 mediated one-pot reaction under ultrasonic irradiation

S Johnpasha, V Nasipireddy… - Polycyclic Aromatic …, 2024 - Taylor & Francis
A general strategy was developed for the synthesis of fused pyrido [3, 2, 1-ij][1–3] triazolo [4,
5-c] quinolinones from 1-(3-iodoprop-2-yn-1-yl)-4-methylquinolin-2 (1 H)-one and several …

Fused Imidazo [2, 1‐b][1, 2, 3] triazolo [4, 5‐d][1, 3] thiazines: One‐Pot Synthesis, Antibiofilim, Bactericidal Effects, and in silico Studies

N Ramu, TM Krishna, V Nasipireddy… - …, 2023 - Wiley Online Library
It has been reported that biologically active organic probe underwent a highly adaptive,
efficient and selective “Click followed by C− N bond coupling” by the use of PEG‐400 in …

Synthesis of novel imidazolo-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine hybrids as in vitro EGFR inhibitors

JMR Velidandla, SK Koppula - Chemical Biology Letters, 2023 - pubs.thesciencein.org
The synthesis of new hybrid [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine derivatives of
imidazole (5a–5m) and their structure determination using 1HNMR, 13CNMR and mass …

Fused Imidazo [1, 2‐d][1, 2, 4] Thiadiazolo [1, 2, 3] Triazoles: One‐Pot Synthesis, Anti‐Bacterial, Anti‐Biofilm and TLR4 Inhibitory Activities

K Premalatha, M Azam, R Kapavarapu… - …, 2024 - Wiley Online Library
We developed and evaluated several new fused imidazo [1, 2‐d][1, 2, 4] thiadiazolo [1, 2, 3]
triazoles to see how they perform against bacteria and biofilms. Some compounds showed …

Synthesis of 1, 2, 3-triazole-piperazin-benzo [b][1, 4] thiazine 1, 1-dioxides: antibacterial, hemolytic and in silico TLR4 protein inhibitory activities

N Ramu, TM Krishna, R Kapavarapu, S Narsimha - RSC advances, 2024 - pubs.rsc.org
In this study, we designed and synthesized a number of novel 1, 2, 3-triazole-piperazin-
benzo [b][1, 4] thiazine 1, 1-dioxide derivatives and investigated their in vitro antibacterial …