RecA: regulation and mechanism of a molecular search engine
JC Bell, SC Kowalczykowski - Trends in biochemical sciences, 2016 - cell.com
Homologous recombination maintains genomic integrity by repairing broken chromosomes.
The broken chromosome is partially resected to produce single-stranded DNA (ssDNA) that …
The broken chromosome is partially resected to produce single-stranded DNA (ssDNA) that …
DNA repair: the search for homology
JE Haber - Bioessays, 2018 - Wiley Online Library
The repair of chromosomal double‐strand breaks (DSBs) by homologous recombination is
essential to maintain genome integrity. The key step in DSB repair is the RecA/Rad51 …
essential to maintain genome integrity. The key step in DSB repair is the RecA/Rad51 …
In situ genome sequencing resolves DNA sequence and structure in intact biological samples
INTRODUCTION Genomes are spatially organized across length scales from single base
pairs to whole chromosomes. This organization is thought to regulate gene expression and …
pairs to whole chromosomes. This organization is thought to regulate gene expression and …
Rad54 drives ATP hydrolysis-dependent DNA sequence alignment during homologous recombination
Homologous recombination (HR) helps maintain genome integrity, and HR defects give rise
to disease, especially cancer. During HR, damaged DNA must be aligned with an …
to disease, especially cancer. During HR, damaged DNA must be aligned with an …
Cohesin regulates homology search during recombinational DNA repair
Homologous recombination repairs DNA double-strand breaks (DSB) using an intact dsDNA
molecule as a template. It entails a homology search step, carried out along a conserved …
molecule as a template. It entails a homology search step, carried out along a conserved …
Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm
AG Hinch, G Zhang, PW Becker, D Moralli, R Hinch… - Science, 2019 - science.org
INTRODUCTION In diploid organisms, the two chromosomes in each homologous pair act
independently of each other during most cellular functions. An exception occurs in meiosis …
independently of each other during most cellular functions. An exception occurs in meiosis …
Multi-invasions are recombination byproducts that induce chromosomal rearrangements
Inaccurate repair of broken chromosomes generates structural variants that can fuel
evolution and inflict pathology. We describe a novel rearrangement mechanism in which …
evolution and inflict pathology. We describe a novel rearrangement mechanism in which …
DNA damage-induced nucleosome depletion enhances homology search independently of local break movement
To determine whether double-strand break (DSB) mobility enhances the physical search for
an ectopic template during homology-directed repair (HDR), we tested the effects of factors …
an ectopic template during homology-directed repair (HDR), we tested the effects of factors …
Editing Transgenic DNA Components by Inducible Gene Replacement in Drosophila melanogaster
Gene conversions occur when genomic double-strand DNA breaks (DSBs) trigger
unidirectional transfer of genetic material from a homologous template sequence …
unidirectional transfer of genetic material from a homologous template sequence …
Mechanism of homology search expansion during recombinational DNA break repair in Saccharomyces cerevisiae
A Dumont, N Mendiboure, J Savocco, L Anani… - Molecular Cell, 2024 - cell.com
Homology search is a central step of DNA double-strand break (DSB) repair by homologous
recombination (HR). How it operates in cells remains elusive. We developed a Hi-C-based …
recombination (HR). How it operates in cells remains elusive. We developed a Hi-C-based …