Incredible strides have been made since the discovery of insulin almost 100 years ago.
Insulin formulations have improved dramatically, glucose levels can be measured …

Clinical islet transplantation: is the future finally now? : Current Opinion in Organ
Transplantation Clinical islet transplantation: is the future finally now? : Current Opinion in …

Synthetic biology has advanced the design of standardized transcription control devices that
programme cellular behaviour. By coupling synthetic signalling cascade-and transcription …

Beta cell replacement has the potential to restore euglycemia in patients with insulin-
dependent diabetes. Although great progress has been made in establishing allogeneic …

Beta-cell replacement therapy is an effective means to restore glucose homeostasis in select
humans with autoimmune diabetes. The scarcity of" healthy" human donor pancreata …

The production of fully functional insulin-secreting cells to treat diabetes is a major goal of
regenerative medicine. In this article, I review progress towards this goal over the last 15 …

Pancreatic progenitors derived from human embryonic stem cells (hESCs) are now in
clinical trials for insulin replacement in patients with type 1 diabetes. Animal studies indicate …

β cell replacement with either pancreas or islet transplantation has progressed immensely
over the last decades with current 1-and 5-year insulin independence rates of approximately …

Background Diabetes mellitus is a devastating metabolic disease. Generation of insulin-
producing cells (IPCs) from stem cells, especially from Wharton's jelly mesenchymal stem …

Pancreatic progenitors derived from human embryonic stem cells (hESCs) are a potential
source of transplantable cells for treating diabetes and are currently being tested in clinical …