In current scenario skin cancer is a serious condition that has a significant impact on world
health. Skin cancer is divided into two categories: melanoma skin cancer (MSC) and non …

The innate immune system plays a critical role in pathogen recognition and initiation of
protective immune response through the recognition of pathogen associated molecular …

Systemic sclerosis (SSc) is a multisystem life-threatening fibrosing disorder that lacks
effective treatment. The link between the inflammation observed in organs such as the skin …

The method of choice for the development of new vaccines is to target distinct dendritic cell
subsets with antigen in vivo and to harness their function in situ to enhance cell-mediated …

The endosomal Toll-like receptors (TLRs) TLR3, TLR7, TLR8 and TLR9 are important in
sensing foreign nucleic acids encountered by phagocytes. Because TLR8 was initially …

Toll-like receptors (TLRs) are nucleic acid–sensing receptors and have been implicated in
mediating pain and itch. Here we report that Tlr8−/− mice show normal itch behaviors, but …

Studies on the role of the RNA receptor TLR8 in inflammation have been limited by its
different function in human versus rodents. We have generated multiple lines of transgenic …

Toll like receptors (TLR) s have a central role in regulating innate immunity and in the last
decade studies have begun to reveal their significance in potentiating autoimmune diseases …

Inborn errors of immunity (IEI) are a genetically heterogeneous group of disorders with a
broad clinical spectrum. Identification of molecular and functional bases of these disorders is …

The mammalian host has developed a long-standing symbiotic relationship with a
considerable number of microbial species. These include the microbiota on environmental …