The phenotypic and functional complexities of T cells engender complicated and often
confusing concepts as to how T cells ignite, accelerate and brake the inflammatory …

A robust adaptive immune response is essential for combatting pathogens. In the wrong
context such as due to genetic and environmental factors, however, the same mechanisms …

Diabetic chronic wounds are notoriously difficult to heal as a result of their susceptibility to
infection. To address this issue, we constructed an innovated and adaptable solution in the …

Given that the extracellular matrix polymer hyaluronan (HA) has been implicated in
longevity, we asked whether 4-methylumbelliferone (4-MU), an inhibitor of HA synthesis …

Syntaxin 4 (STX4), a plasma membrane–localized SNARE protein, regulates human islet β-
cell insulin secretion and preservation of β-cell mass. We found that human type 1 diabetes …

Background Considered a significant risk to health and survival, type 1 diabetes (T1D) is a
heterogeneous autoimmune disease characterized by hyperglycemia caused by an …

Multiple rodent models have been developed to study the basis of type 1 diabetes (T1D).
However, nonobese diabetic (NOD) mice and derivative strains still provide the gold …

The extracellular matrix (ECM) provides an appropriate microenvironment for many kinds of
cells, including pancreatic cells. Collagens are the most abundant components of the ECM …

Biodegradable elastomeric controlled-release poly (decane-co-tricarballylate)(PDET) based
matrices capable of maintaining the stability and bioactivity of Interleukin-2 (IL-2) through the …

Over the past few decades, regulatory T cell (Treg) therapy has gained traction for the
treatment of autoimmunity, transplant rejection, and other inflammatory diseases. A …