Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …

Neural crest cells are embryonic progenitors that generate numerous cell types in
vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become …

Activation and accumulation of cardiac fibroblasts, which result in excessive extracellular
matrix deposition and consequent mechanical stiffness, myocyte uncoupling, and ischemia …

Fibroblasts comprise the largest cell population in the myocardium. In heart disease, the
number of fibroblasts is increased either by replication of the resident myocardial fibroblasts …

Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence
indicates that the mitral valve is not a passive structure, but—even in adult life—remains …

Cardiac stress can induce morphological, structural and functional changes of the heart,
referred to as cardiac remodeling. Myocardial infarction or sustained overload as a result of …

Fibroblasts are at the heart of cardiac function and are the principal determinants of cardiac
fibrosis. Nevertheless, cardiac fibroblasts remain poorly characterized in molecular terms …

The cardiomyocyte (CM) subtypes in the mammalian heart derive from distinct lineages
known as the first heart field (FHF), the anterior second heart field (aSHF), and the posterior …

The mature heart valves are made up of highly organized extracellular matrix (ECM) and
valve interstitial cells (VICs) surrounded by an endothelial cell layer. The ECM of the valves …