Bioinorganic photochemistry: frontiers and mechanisms

K Szaciłowski, W Macyk… - Chemical …, 2005 - ACS Publications
For more than 50 years bioinorganic chemistry has remained an expanding and exciting
interdisciplinary field of science. 1-6 One of the rapidly growing and evolving new research …

The contribution of an imbalanced redox signalling to neurological and neurodegenerative conditions

JR Steinert, H Amal - Free Radical Biology and Medicine, 2023 - Elsevier
Nitric oxide and other redox active molecules such as oxygen free radicals provide essential
signalling in diverse neuronal functions, but their excess production and insufficient …

[PDF][PDF] Whole brain emulation: A roadmap

A Sandberg, N Bostrom - 2008 - ora.ox.ac.uk
Whole Brain Emulation: A Roadmap Page 1 Whole Brain Emulation A Roadmap (2008)
Technical Report #2008-3 Anders Sandberg* Nick Bostrom Future of Humanity Institute …

Nitric oxide, cell signaling and cell death

GA Blaise, D Gauvin, M Gangal, S Authier - Toxicology, 2005 - Elsevier
Nitric oxide (NO) is an important bioregulatory molecule in the nervous, immune and
cardiovascular systems. NO participates in the regulation of the daily activities of cells as …

Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidase

MG Mason, P Nicholls, MT Wilson… - Proceedings of the …, 2006 - National Acad Sciences
NO reversibly inhibits mitochondrial respiration via binding to cytochrome c oxidase (CCO).
This inhibition has been proposed to be a physiological control mechanism and/or to …

Medical gas therapy for tissue, organ, and CNS protection: a systematic review of effects, mechanisms, and challenges

RD Zafonte, L Wang, CA Arbelaez… - Advanced …, 2022 - Wiley Online Library
Gaseous molecules have been increasingly explored for therapeutic development. Here,
following an analytical background introduction, a systematic review of medical gas …

NO Dioxygenase Activity in Hemoglobins Is Ubiquitous In Vitro, but Limited by Reduction In Vivo

BJ Smagghe, JT Trent III, MS Hargrove - PloS one, 2008 - journals.plos.org
Genomics has produced hundreds of new hemoglobin sequences with examples in nearly
every living organism. Structural and biochemical characterizations of many recombinant …

Neuroprotective Activity of Melittin—The Main Component of Bee Venom—Against Oxidative Stress Induced by Aβ25–35 in In Vitro and In Vivo Models

CD Nguyen, G Lee - Antioxidants, 2021 - mdpi.com
Melittin, a 26-amino acid peptide, is the main component of the venom of four honeybee
species and exhibits neuroprotective actions. However, it is unclear how melittin ameliorates …

Nitric oxide regulation of mitochondrial oxygen consumption I: cellular physiology

C Giulivi, K Kato, CE Cooper - American Journal of …, 2006 - journals.physiology.org
Mitochondrial biochemistry is complex, expanding from oxygen consumption, oxidative
phosphorylation, lipid catabolism, heme biosynthesis, to apoptosis, calcium homeostasis …

Bee Venom Activates the Nrf2/HO-1 and TrkB/CREB/BDNF Pathways in Neuronal Cell Responses against Oxidative Stress Induced by Aβ1–42

CD Nguyen, J Yoo, SY Hwang, SY Cho, M Kim… - International Journal of …, 2022 - mdpi.com
Honeybee venom has recently been considered an anti-neurodegenerative agent, primarily
due to its anti-inflammatory effects. The natural accumulation of amyloid-beta (Aβ) in the …