International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
[HTML][HTML] The microbiome and irritable bowel syndrome–a review on the pathophysiology, current research and future therapy
Irritable bowel syndrome (IBS) is a functional disorder which affects a large proportion of the
population globally. The precise etiology of IBS is still unknown, although consensus …
population globally. The precise etiology of IBS is still unknown, although consensus …
Bowel disorders
BE Lacy, F Mearin, L Chang, WD Chey, AJ Lembo… - Gastroenterology, 2016 - Elsevier
Functional bowel disorders are highly prevalent disorders found worldwide. These disorders
have the potential to affect all members of society, regardless of age, sex, race, creed, color …
have the potential to affect all members of society, regardless of age, sex, race, creed, color …
Disorders of the enteric nervous system—a holistic view
The enteric nervous system (ENS) is the largest division of the peripheral nervous system
and closely resembles components and functions of the central nervous system. Although …
and closely resembles components and functions of the central nervous system. Although …
Intestinal barrier function in health and gastrointestinal disease
Defects in intestinal barrier function are associated with diseases of the gastrointestinal (GI)
tract. There is growing evidence that increases in intestinal permeability plays a pathogenic …
tract. There is growing evidence that increases in intestinal permeability plays a pathogenic …
[HTML][HTML] The enteric nervous system in gastrointestinal disease etiology
AM Holland, AC Bon-Frauches, D Keszthelyi… - Cellular and Molecular …, 2021 - Springer
A highly conserved but convoluted network of neurons and glial cells, the enteric nervous
system (ENS), is positioned along the wall of the gut to coordinate digestive processes and …
system (ENS), is positioned along the wall of the gut to coordinate digestive processes and …
Genome‐wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis
MicroRNAs (miRNAs) are studied as key regulators of gene expression involved in different
diseases. Several single nucleotide polymorphisms (SNPs) in miRNA genes or target sites …
diseases. Several single nucleotide polymorphisms (SNPs) in miRNA genes or target sites …
SNPs in microRNA target sites and their potential role in human disease
A Moszyńska, M Gebert, JF Collawn… - Open …, 2017 - royalsocietypublishing.org
In the post-genomic era, the goal of personalized medicine is to determine the correlation
between genotype and phenotype. Developing high-throughput genotyping technologies …
between genotype and phenotype. Developing high-throughput genotyping technologies …
[HTML][HTML] The role of visceral hypersensitivity in irritable bowel syndrome: pharmacological targets and novel treatments
MH Farzaei, R Bahramsoltani, M Abdollahi… - Journal of …, 2016 - ncbi.nlm.nih.gov
Irritable bowel syndrome (IBS) is the most common disorder referred to gastroenterologists
and is characterized by altered bowel habits, abdominal pain, and bloating. Visceral …
and is characterized by altered bowel habits, abdominal pain, and bloating. Visceral …
Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome
S Buhner, Q Li, S Vignali, G Barbara, R De Giorgio… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Pathological features in irritable bowel syndrome (IBS) include
alterations in mucosal cell content and release of mediators that might alter signaling to …
alterations in mucosal cell content and release of mediators that might alter signaling to …