Muscarinic acetylcholine receptor agonists as novel treatments for schizophrenia

SM Paul, SE Yohn, M Popiolek… - American Journal of …, 2022 - Am Psychiatric Assoc
Schizophrenia remains a challenging disease to treat effectively with current antipsychotic
medications due to their limited efficacy across the entire spectrum of core symptoms as well …

New developments in the treatment of schizophrenia: an expert roundtable

JT Kantrowitz, CU Correll, R Jain… - International Journal of …, 2023 - academic.oup.com
Background Schizophrenia is a disabling disorder that profoundly affects functioning and
quality of life. While available antipsychotics have improved outcomes for patients with …

Normative modelling of molecular-based functional circuits captures clinical heterogeneity transdiagnostically in psychiatric patients

T Lawn, A Giacomel, D Martins, M Veronese… - Communications …, 2024 - nature.com
Advanced methods such as REACT have allowed the integration of fMRI with the brain's
receptor landscape, providing novel insights transcending the multiscale organisation of the …

Normative Modelling of Molecular-based Functional Neurocircuits Captures Clinical Heterogeneity Transdiagnostically in Neuropsychiatric Patients

T Lawn, A Giacomel, D Martins, M Veronese… - bioRxiv, 2023 - biorxiv.org
Clinical neuroscience principally aims to delineate the neurobiology underpinning the
symptoms of various disorders, with the ultimate goal of developing mechanistically …