Trop2 is a transmembrane glycoprotein and calcium signal transducer with limited
expression in normal human tissues. It is consistently overexpressed in a variety of …

Simple Summary Metastatic progression represents a major clinical challenge and remains
the leading cause of death in cancer patients. Identification of suitable therapeutic targets …

CAR (chimeric antigen receptor) T cell therapy has shown clinical success in treating
hematological malignancies, but its treatment of solid tumors has been limited. One major …

Trop-2 is a transmembrane signal transducer that can induce cancer growth. Using antibody
targeting and N-terminal Edman degradation, we show here that Trop-2 undergoes …

Introduction Tumor-associated calcium signal transducer 2 (Trop2) has been used as a
transport gate for cytotoxic agents into cells in antibody–drug conjugate designs because of …

Trop2 is a cell-surface transmembrane glycoprotein involved in the maintenance of
epithelial tissue integrity and is an important carcinoma marker. It shares similar claudin …

Human trophoblast cell surface antigen 2 (TROP-2) is an important target of tumor therapy,
and antibody-drug conjugates with sacituzumab targeting TROP-2 have been approved for …

The Trop-2–targeting antibody-drug conjugate (ADC) sacituzumab govitecan (SG) has been
approved by the US Food and Drug Administration and European Medicines Agency for …

Abstract Trophoblast antigen 2 (Trop2) is a type I transmembrane protein post-translationally
modified by N-linked glycosylation. It was originally detected in trophoblasts but was later …

Simple Summary Colorectal cancer (CRC) is one of the most common cancers worldwide.
While the systemic treatment of CRC is based on chemotherapy, subsequent therapeutic …