Epistasis in protein evolution
TN Starr, JW Thornton - Protein science, 2016 - Wiley Online Library
The structure, function, and evolution of proteins depend on physical and genetic
interactions among amino acids. Recent studies have used new strategies to explore the …
interactions among amino acids. Recent studies have used new strategies to explore the …
Causes of molecular convergence and parallelism in protein evolution
JF Storz - Nature Reviews Genetics, 2016 - nature.com
To what extent is the convergent evolution of protein function attributable to convergent or
parallel changes at the amino acid level? The mutations that contribute to adaptive protein …
parallel changes at the amino acid level? The mutations that contribute to adaptive protein …
VARIDT 2.0: structural variability of drug transporter
The structural variability data of drug transporter (DT) are key for research on precision
medicine and rational drug use. However, these valuable data are not sufficiently covered …
medicine and rational drug use. However, these valuable data are not sufficiently covered …
Biophysics of protein evolution and evolutionary protein biophysics
The study of molecular evolution at the level of protein-coding genes often entails comparing
large datasets of sequences to infer their evolutionary relationships. Despite the importance …
large datasets of sequences to infer their evolutionary relationships. Despite the importance …
Genes, mutations, and human inherited disease at the dawn of the age of personalized genomics
The number of reported germline mutations in human nuclear genes, either underlying or
associated with inherited disease, has now exceeded 100,000 in more than 3,700 different …
associated with inherited disease, has now exceeded 100,000 in more than 3,700 different …
Protein co‐evolution, co‐adaptation and interactions
F Pazos, A Valencia - The EMBO journal, 2008 - embopress.org
Co‐evolution has an important function in the evolution of species and it is clearly
manifested in certain scenarios such as host–parasite and predator–prey interactions …
manifested in certain scenarios such as host–parasite and predator–prey interactions …
Identification of cis-suppression of human disease mutations by comparative genomics
Patterns of amino acid conservation have served as a tool for understanding protein
evolution. The same principles have also found broad application in human genomics …
evolution. The same principles have also found broad application in human genomics …
Compensatory mutations and epistasis for protein function
JF Storz - Current opinion in structural biology, 2018 - Elsevier
Highlights•Adaptive protein evolution may be facilitated by conditionally neutral
mutations.•Mutations can have different effects on different genetic backgrounds.• …
mutations.•Mutations can have different effects on different genetic backgrounds.• …
Phylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations
Modern technologies have made the sequencing of personal genomes routine. They have
revealed thousands of nonsynonymous (amino acid altering) single nucleotide variants …
revealed thousands of nonsynonymous (amino acid altering) single nucleotide variants …
Structural and functional roles of coevolved sites in proteins
S Chakrabarti, AR Panchenko - PloS one, 2010 - journals.plos.org
Background Understanding the residue covariations between multiple positions in protein
families is very crucial and can be helpful for designing protein engineering experiments …
families is very crucial and can be helpful for designing protein engineering experiments …