Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming
proteins that are critically involved in many aspects of vascular physiology and pathology …

HMGB1 is a chromosome-binding protein that also acts as a damage-associated molecular
pattern molecule. It has potent proinflammatory effects and is one of key mediators of organ …

Fruits and vegetables (typically associated with the Mediterranean diet) are very rich in
carotenoids, ie fat-soluble pigments really important in human life. Structurally, carotenoids …

Background Hydrogen sulfide (H 2 S), as a newly identified gaseous mediator, has been
widely investigated in various systems. However, the effect of H 2 S on cardiovascular …

Understanding the pharmacodynamics of cannabinoids is an essential subject due to the
recent increasing global acceptance of cannabis and its derivation for recreational and …

Although, several novel forms of intervention aiming at newly identified therapeutic targets
are currently being developed for diabetes mellitus (DM), it is well established that physical …

Objective Shear stress patterns influence atherogenesis and plaque stability; low laminar
shear stress (LLSS) promotes unstable plaques whereas oscillatory shear stress (OSS) …

Objective—To determine whether impairment of endothelial connexin40 (Cx40), an effect
that can occur in hypertension and aging, contributes to the arterial dysfunction and …

New technology has enabled recovery of inaccessible natural gas shale deposits; however,
the potential impacts to human health from the migration of brines into drinking water or …