Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …

Cancer immunity is subject to spatiotemporal regulation by leukocyte interaction with the
tumor microenvironment. Growing evidence suggests an emerging role for the vasculature …

Background & aims Combination immunotherapy refers to the use of immune checkpoint
inhibitors (ICI) and molecular-targeted agents (MTA), which have recently been approved for …

Microphysiological systems (MPSs), also known as organ-on-chip or disease-on-chip, have
recently emerged to reconstitute the in vivo cellular microenvironment of various organs and …

Background Melanoma brain metastases (MBM) continue to be a significant clinical problem
with limited treatment options. Highly invasive melanoma cells migrate along the vasculature …

Sustained angiogenesis stands as a hallmark of cancer. The intricate vascular tumor
microenvironment fuels cancer progression and metastasis, fosters therapy resistance, and …

T cell scarcity in tumor tissues poses a critical challenge to cancer immunotherapy. Here we
manipulate the tumor vasculature, an essential regulator of immune cell trafficking, to …