[HTML][HTML] New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)

CP Palanisamy, JJ Pei, P Alugoju, NVA Anthikapalli… - Theranostics, 2023 - ncbi.nlm.nih.gov
Neurodegenerative diseases are characterized by the progressive loss of neurons and
intricate interactions between different cell types within the affected regions. Reliable …

Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery

T Burnouf, ML Chou, DJ Lundy, EY Chuang… - Journal of Biomedical …, 2023 - Springer
Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …

Network approach in liquidomics landscape

D Santini, A Botticelli, A Galvano, M Iuliani… - Journal of Experimental …, 2023 - Springer
Tissue-based biopsy is the present main tool to explore the molecular landscape of cancer,
but it also has many limits to be frequently executed, being too invasive with the risk of side …

Mesenchymal stem cells under epigenetic control–the role of epigenetic machinery in fate decision and functional properties

A Walewska, A Janucik, M Tynecka, M Moniuszko… - Cell Death & …, 2023 - nature.com
Mesenchymal stem cells (mesenchymal stromal cells, MSC) are multipotent stem cells that
can differentiate into cells of at least three mesodermal lineages, namely adipocytes …

Platelet-derived extracellular vesicles for drug delivery

C Yao, C Wang - Biomaterials Science, 2023 - pubs.rsc.org
Platelet-derived extracellular vesicles (PEVs) are a subset of EVs that are released from
platelets, which are small nuclear cell fragments that play a critical role in hemostasis and …

Shedding light on the cell biology of platelet-derived extracellular vesicles and their biomedical applications

PK Chaudhary, S Kim, S Kim - Life, 2023 - mdpi.com
EVs are membranous subcellular structures originating from various cells, including
platelets which consist of biomolecules that can modify the target cell's pathophysiological …

GelMA loaded with platelet lysate promotes skin regeneration and angiogenesis in pressure ulcers by activating STAT3

T Jin, Z Fu, L Zhou, L Chen, J Wang, L Wang, S Yan… - Scientific Reports, 2024 - nature.com
Pressure ulcers (PU) are caused by persistent long-term pressure, which compromises the
integrity of the epidermis, dermis, and subcutaneous adipose tissue layer by layer, making it …

Cell Type-Specific Extracellular Vesicles and Their Impact on Health and Disease

S Amin, H Massoumi, D Tewari, A Roy… - International Journal of …, 2024 - mdpi.com
Extracellular vesicles (EVs), a diverse group of cell-derived exocytosed particles, are pivotal
in mediating intercellular communication due to their ability to selectively transfer …

Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization

K Jia, J You, Y Zhu, M Li, S Chen, S Ren… - … in Bioengineering and …, 2024 - frontiersin.org
Platelet-rich fibrin, a classical autologous-derived bioactive material, consists of a fibrin
scaffold and its internal loading of growth factors, platelets, and leukocytes, with the gradual …

Human platelet lysate combined with mesenchymal stem cells pretreated with platelet lysate improved cardiac function in rats with myocardial infarction

H Najafipour, F Rostamzadeh… - Scientific Reports, 2024 - nature.com
Myocardial infarction (MI) is a leading cause of heart failure, disability and mortality
worldwide. In this study, the effects of intramyocardial injection of human platelet lysate …