T and B cells express most cholinergic system components—eg, acetylcholine (ACh),
choline acetyltransferase (ChAT), acetylcholinesterase, and both muscarinic and nicotinic …

Alzheimer's disease (AD) is a multifactorial syndrome resulting in profound misery and
poses a substantial burden on human health, economy, and society throughout the world …

Background. Cholinesterases are a group of serine hydrolases that split the neurotransmitter
acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and …

Both Alzheimer's disease (AD) and Type 2 diabetes mellitus (T2DM) share the presence of
systemic and neuro-inflammation, enhanced production and accumulation of β-amyloid …

This review examines the large body of toxicological and epidemiological information on
human exposures to chlorpyrifos, with an emphasis on the controversial potential for …

Objective: To examine the role of butyrylcholinesterase (BuChE) in cholinergic signaling and
neurologic conditions, such as Alzheimer's disease (AD). The rationale for inhibiting …

An important aspect of brain cholinesterase function is related to enzymatic differences. The
brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) …

Acetylcholinesterase (AChE) predominates in the healthy brain, with butyrylcholinesterase
(BuChE) considered to play a minor role in regulating brain acetylcholine (ACh) levels …

Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …

Alzheimer's disease (AD) is an age-related neurodegenerative disease that affects
approximately 4.5 million people in the United States. The mainstays of current …