Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

The skin, being the largest organ in the human body, is exposed to the environment and
suffers from both intrinsic and extrinsic aging factors. The skin aging process is …

The active metabolites of vitamin D3 (D3) and lumisterol (L3) exert a variety of antiaging and
photoprotective effects on the skin. These are achieved through immunomodulation and …

There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

The mitochondrial free radical theory of aging suggests that accumulating oxidative damage
to mitochondria and mitochondrial DNA (mtDNA) plays a central role in aging. Circulating …

Background Mitochondrial dysfunction is a feature of neurodegenerative diseases, including
Alzheimer's disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and …

Skin aging is accompanied by a gradual loss of function, physiological integrity and the
ability to cope with internal and external stressors. This is secondary to a combination of …

Using a high-throughput mitochondrial phenotyping platform to quantify multiple
mitochondrial features among molecularly defined immune cell subtypes, we quantify the …