The impact of SGLT2 inhibitors on inflammation: A systematic review and meta-analysis of studies in rodents
Background Inhibition of sodium-glucose cotransporter-2 (SGLT2) has received remarkable
attention due to the beneficial effects observed in diabetes mellitus, heart failure, and kidney …
attention due to the beneficial effects observed in diabetes mellitus, heart failure, and kidney …
Anti-inflammatory properties of antidiabetic drugs: a “promised land” in the COVID-19 era?
N Katsiki, E Ferrannini - Journal of Diabetes and its Complications, 2020 - Elsevier
Inflammation is implicated in the development and severity of the coronavirus disease 2019
(COVID-19), as well as in the pathophysiology of diabetes. Diabetes, especially when …
(COVID-19), as well as in the pathophysiology of diabetes. Diabetes, especially when …
Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways
The antidiabetic drug canagliflozin is reported to possess several cardioprotective effects.
However, no studies have investigated protective effects of canagliflozin in isoprenaline …
However, no studies have investigated protective effects of canagliflozin in isoprenaline …
Canagliflozin ameliorates renal oxidative stress and inflammation by stimulating AMPK–Akt–eNOS pathway in the isoprenaline-induced oxidative stress model
Diabetes is a leading cause of chronic kidney disease, and the high prevalence of
sympathetic nervous system (SNS) hyperactivity in diabetic patients makes them further …
sympathetic nervous system (SNS) hyperactivity in diabetic patients makes them further …
Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation
Abstract Aim Cisplatin (Cis) is widely used chemotherapeutic and has some serious side
effects as nephrotoxicity. Phloretin (PH) and Phloridzin (PZ) are known their anti-oxidant anti …
effects as nephrotoxicity. Phloretin (PH) and Phloridzin (PZ) are known their anti-oxidant anti …
Glucose metabolism in acute kidney injury and kidney repair
The kidneys play an indispensable role in glucose homeostasis via glucose reabsorption,
production, and utilization. Conversely, aberrant glucose metabolism is involved in the …
production, and utilization. Conversely, aberrant glucose metabolism is involved in the …
The effects of canagliflozin on gout in type 2 diabetes: a post-hoc analysis of the CANVAS Program
Background Sodium glucose co-transporter 2 inhibitors have been shown to reduce serum
urate concentration. The Canagliflozin Cardiovascular Assessment Study (CANVAS) …
urate concentration. The Canagliflozin Cardiovascular Assessment Study (CANVAS) …
Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice
Canagliflozin (Cana), a clinically important anti-diabetes drug, leads to a 14% increase in
median lifespan and a 9% increase in the 90th percentile age when given to genetically …
median lifespan and a 9% increase in the 90th percentile age when given to genetically …
SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy
Y Oe, YC Kim, VS Sidorenko, H Zhang… - American Journal …, 2024 - journals.physiology.org
Proximal tubular uptake of aristolochic acid (AA) forms aristolactam (AL)-DNA adducts,
which cause a p53/p21-mediated DNA damage response and acute tubular injury …
which cause a p53/p21-mediated DNA damage response and acute tubular injury …
The alleviative effects of canagliflozin on imiquimod-induced mouse model of psoriasis-like inflammation
H Ridha-Salman, AA Al-Zubaidy, AH Abbas… - Naunyn-Schmiedeberg's …, 2024 - Springer
Psoriasis is a life-long immune-mediated dermatosis with thickened, reddish, and flaky skin
patches. Canagliflozin is a gliflozin antidiabetic with non-classical remarkable antioxidative …
patches. Canagliflozin is a gliflozin antidiabetic with non-classical remarkable antioxidative …