Fungal-mediated disease progression and antifungal drug efficacy are significantly
impacted by the dynamic infection microenvironment. At the site of infection, oxygen often …

Schizophrenia is a chronic disease characterized by the impairment of mental functions with
a marked social dysfunction. A quantitative proteomic approach using iTRAQ labeling and …

In 1926, the Journal of Pathology and Bacteriology published the immunological notes of a
little-known diphtheria researcher, AT Glenny. In table XLIII of that publication, he reported …

Abstract The 2‐oxoglutarate (2OG) dependent oxygenases were first identified as having
roles in the post‐translational modification of procollagen in animals. Subsequently in plants …

Sterol regulatory element-binding protein (SREBP), a highly conserved family of membrane-
bound transcription factors, is an essential regulator for cellular cholesterol and lipid …

Understanding the mechanisms triggering variation of cell wall degradability is a
prerequisite to improving the energy value of lignocellulosic biomass for animal feed or …

Sir Peter Ratcliffe Lecture 295 standing of the sensing and signalling of hypoxia that were
made in my laboratory. Homeostasis requires the detection and response to an error signal …

Prolyl hydroxylation functions in diverse cellular pathways, such as collagen biogenesis,
oxygen sensing, and translation termination. Prolyl hydroxylation is catalyzed by 2 …

Ageing is a malleable process and outstanding discoveries demonstrate that: 1) a single
point mutation can double the lifespan of model organisms, 2) these long-lived animals are …