The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

Palmitoylethanolamide (PEA) has emerged as a potential nutraceutical, because this
compound is naturally produced in many plant and animal food sources, as well as in cells …

Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent
flavor. Understanding the actions of capsaicin led to the discovery of its receptor, transient …

Deep brain stimulation (DBS) has long been used to alleviate symptoms in patients suffering
from psychiatric and neurological disorders through stereotactically implanted electrodes …

Objective: This review discusses the relationship between cannabis use and psychotic,
bipolar, depressive, and anxiety disorders, as well as suicide. It summarizes epidemiological …

Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient
receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved …

The endocannabinoid system was revealed following the understanding of the mechanism
of action of marijuana's major psychotropic principle, Δ 9-tetrahydrocannabinol, and …

Synaptic modifications in the nucleus accumbens (NAc) are important for adaptive and
pathological reward-dependent learning. Medium spiny neurons (MSNs), the major cell type …

The endocannabinoid system (ECS), comprising two G protein-coupled receptors (the
cannabinoid receptors 1 and 2 [CB1 and CB2] for marijuana's psychoactive principle∆ 9 …

The development of antagonists of the transient receptor potential vanilloid-1 (TRPV1)
channel as pain therapeutics has revealed that these compounds cause hyperthermia in …