Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen
JD Radolf, RK Deka, A Anand, D Šmajs… - Nature Reviews …, 2016 - nature.com
The past two decades have seen a worldwide resurgence in infections caused by
Treponema pallidum subsp. pallidum, the syphilis spirochete. The well-recognized capacity …
Treponema pallidum subsp. pallidum, the syphilis spirochete. The well-recognized capacity …
Biological basis for syphilis
RE LaFond, SA Lukehart - Clinical microbiology reviews, 2006 - Am Soc Microbiol
Syphilis is a chronic sexually transmitted disease caused by Treponema pallidum subsp.
pallidum. Clinical manifestations separate the disease into stages; late stages of disease are …
pallidum. Clinical manifestations separate the disease into stages; late stages of disease are …
Syphilis: using modern approaches to understand an old disease
EL Ho, SA Lukehart - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
Syphilis is a fascinating and perplexing infection, with protean clinical manifestations and
both diagnostic and management ambiguities. Treponema pallidum subsp. pallidum, the …
both diagnostic and management ambiguities. Treponema pallidum subsp. pallidum, the …
Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar
NAP Lieberman, MJ Lin, H Xie, L Shrestha… - PLoS neglected …, 2021 - journals.plos.org
In spite of its immutable susceptibility to penicillin, Treponema pallidum (T. pallidum) subsp.
pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in …
pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in …
The endemic treponematoses
L Giacani, SA Lukehart - Clinical microbiology reviews, 2014 - Am Soc Microbiol
The agents of human treponematoses include four closely related members of the genus
Treponema: three subspecies of Treponema pallidum plus Treponema carateum. T …
Treponema: three subspecies of Treponema pallidum plus Treponema carateum. T …
The immunopathobiology of syphilis: the manifestations and course of syphilis are determined by the level of delayed-type hypersensitivity
JA Carlson, G Dabiri, B Cribier… - The American journal of …, 2011 - journals.lww.com
Syphilis has plagued mankind for centuries and is currently resurgent in the Western
hemisphere. Although there has been a significant reduction of tertiary disease and …
hemisphere. Although there has been a significant reduction of tertiary disease and …
Virulence factors of the oral spirochete Treponema denticola
SG Dashper, CA Seers, KH Tan… - Journal of dental …, 2011 - journals.sagepub.com
There is compelling evidence that treponemes are involved in the etiology of several chronic
diseases, including chronic periodontitis as well as other forms of periodontal disease …
diseases, including chronic periodontitis as well as other forms of periodontal disease …
On the origin of the treponematoses: a phylogenetic approach
Background Since the first recorded epidemic of syphilis in 1495, controversy has
surrounded the origins of the bacterium Treponema pallidum subsp. pallidum and its …
surrounded the origins of the bacterium Treponema pallidum subsp. pallidum and its …
POTRA: a conserved domain in the FtsQ family and a class of β-barrel outer membrane proteins
L Sánchez-Pulido, D Devos, S Genevrois… - Trends in biochemical …, 2003 - cell.com
POTRA (for polypeptide-transport-associated domain) is a novel domain identified in
proteins of the ShlB, Toc75, D15 and FtsQ/DivIB families. In most cases, the POTRA domain …
proteins of the ShlB, Toc75, D15 and FtsQ/DivIB families. In most cases, the POTRA domain …
Molecular architecture and function of the Omp85 family of proteins
IE Gentle, L Burri, T Lithgow - Molecular microbiology, 2005 - Wiley Online Library
Omp85 is a protein found in Gram‐negative bacteria where it serves to integrate proteins
into the bacterial outer membrane. Members of the Omp85 family of proteins are defined by …
into the bacterial outer membrane. Members of the Omp85 family of proteins are defined by …