Since Late-onset Alzheimer's disease (LOAD) derives from a combination of genetic variants
and environmental factors, epigenetic modifications have been predicted to play a role in the …

Fingolimod is a well-tolerated, highly effective disease-modifying therapy successfully
utilized in the management of multiple sclerosis. The active metabolite, fingolimod …

Hypoxic-ischemic brain damage (HIBD) is the main cause of perinatal mortality and
neurologic complications in neonates, but it remains difficult to cure due to scarce treatments …

Dopamine and serotonin signalling are associated with major depressive disorder, which is
a prevalent life-threatening illness worldwide. Numerous FDA-approved …

Background Smilagenin (SMI) is a lipid-soluble steroidal sapogenin, extracted from
traditional Chinses medicinal herbs Radix Asparagi, which is extracted from the dry root of …

The importance of HDAC3 in transcriptional regulation of genes associated with long-term
memory is well established. Here, we report a novel HDAC3 inhibitor, PT3, with an excellent …

Alcohol use disorder (AUD) is a public health issue that affects millions of people worldwide
leading to physical, mental and socio-economic consequences. While current treatments for …

Neurotrophins play a major role in the regulation of neuronal growth such as neurite
sprouting or regeneration in response to nerve injuries. The role of nerve growth factor …

Vascular dementia (VaD) is the second most common cause of dementia, but the treatment
is still lacking. Although many studies have reported that histone deacetylase inhibitors …

For multicellular organisms, it is essential to produce a variety of specialized cells to perform
a dazzling panoply of functions. Chromatin plays a vital role in determining cellular …