Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Resistance to therapy is the major hurdle in the current cancer management. Cancer cells
often rewire their cellular process to alternate mechanisms to resist the deleterious effect …

Ionizing radiation (IR), such as X-rays and gamma (γ)-rays, mediates various forms of cancer
cell death such as apoptosis, necrosis, autophagy, mitotic catastrophe, and senescence …

Abstract PD-1 blockade (nivolumab) efficacy remains modest for metastatic sarcoma. In this
paper, we present an open-label, non-randomized, non-comparative pilot study of …

Hedgehog signaling pathway is physiologically activated during embryogenesis, especially
in lung development. It is also reactivated in many solid tumors. In lung cancer, Hedgehog …

Head and neck squamous cell carcinoma (HNSCC) is the sixth leading malignancy
worldwide, with a poor prognosis and limited treatment options. Molecularly targeted …

Cervical cancer is the fourth common gynecologic cancer and is considered as second
leading cause of death among women. Various strategies are applied in treatment of …

Background Tumor cell repopulation after radiotherapy is a major cause for the tumor
radioresistance and recurrence. This study aims to investigate the underlying mechanism of …

GLI transcription factors have important roles in intracellular signaling cascade, acting as the
main mediators of the HH-GLI signaling pathway. This is one of the major developmental …