Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

In the dense circulatory system of the kidney, as in all vascularized tissues, pericytes enwrap
capillaries and microvessels to regulate angiogenesis, stabilize microvascular networks and …

Prerequisite to any biological laboratory assay employing living animals is consideration
about its necessity, feasibility, ethics and the potential harm caused during an experiment …

Because of essential role in homeostasis of the body fluid and excretion of wastes, kidney
damage can lead to severe impacts on health and survival of humans. For most chemicals …

Neutrophils and macrophages are crucial effectors and modulators of repair and
regeneration following myocardial infarction, but they cannot be easily observed in vivo in …

Background Podocytes are critical to maintaining the glomerular filtration barrier, and
mutations in nephrotic syndrome genes are known to affect podocyte calcium signaling …

Podocytes, specialized postmitotic cells, are central players in various kidney-related
diseases. Zebrafish have become a valuable model system for studying podocyte biology …

Proteinuria develops when specific components in the glomerular filtration barrier have
impaired function. Although the precise components involved in maintaining this barrier …

Fabry disease (FD) is a rare genetic lysosomal storage disorder, resulting from partial or
complete lack of alpha-galactosidase A (α-GAL) enzyme, leading to systemic accumulation …

Nephrotoxicity is an important drug safety aspect to be assessed during drug discovery and
development. To study renal toxicity, in vitro cell-based assays are often used. Unfortunately …