The current research paradigm for Huntington's disease is based on participants with overt
clinical phenotypes and does not address its pathophysiology nor the biomarker changes …

Purpose: This systematic review examines research and practical applications of the World
Health Organization Disability Assessment Schedule (WHODAS 2.0) as a basis for …

Huntington disease is devastating to patients and their families—with autosomal dominant
inheritance, onset typically in the prime of adult life, progressive course, and a combination …

Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …

Harnessing the potential of human embryonic stem cells to mimic normal and aberrant
development with standardized models is a pressing challenge. Here we use micropattern …

Background Although the association between cytosine-adenine-guanine (CAG) repeat
length and age at onset of Huntington's disease is well known, improved prediction of onset …

Huntington's disease (HD) is currently diagnosed based on the presence of motor signs
indicating 99%“diagnostic confidence” for HD. Recent advances in the understanding of HD …

Huntington disease (HD) is an autosomal dominant, neurodegenerative disorder with a
primary etiology of striatal pathology. The Huntingtin gene (HTT) has a unique feature of a …

Objective To assess the prevalence, timing, and functional impact of psychiatric, cognitive,
and motor abnormalities in Huntington disease (HD) gene carriers, we analyzed …

Understanding the overall progression of neurodegenerative diseases is critical to the timing
of therapeutic interventions and design of effective clinical trials. Disease progression can …