Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that
evolve through a multi-step process. CML is also one of the best examples of a disease that …

The twenty-first century is beginning with a sharp turn in the field of cancer therapy.
Molecular targeted therapies against specific oncogenic events are now possible. The BCR …

The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs.
To address this issue, we developed a clinically applicable strategy for the derivation of …

Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease with distinct biological
and clinical features. The biologic basis of the stereotypical progression from chronic phase …

Altered mRNA translation is one of the effects exerted by the BCR/ABL oncoprotein in the
blast crisis phase of chronic myelogenous leukemia (CML). Here, we report that in …

Sodium n-dodecyl benzene sulfonate (LAS) and sodium dodecyl sulfate (SDS) are popular
anionic detergents (surfactants) that are used worldwide and the toxicities of these …

In this study, we provide a molecular signature of highly enriched CD34+ cells from bone
marrow of untreated patients with chronic myelogenous leukemia (CML) in chronic phase in …

Although the selective tyrosine kinase inhibitor imatinib is successfully used in the treatment
of chronic myeloid leukemia (CML), inherent mechanisms confer primary resistance to …

Despite recent success in the treatment of early-stage disease, blastic phase (BP) of chronic
myeloid leukemia (CML) that is characterized by rapid expansion of therapy-refractory and …

To obtain comprehensive information about the genes involved in BCR/ABL-dependent
leukemogenesis, samples from 15 chronic myelogenous leukemia (CML) patients and …