Development of isatin-thiazolo [3, 2-a] benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and …
In the current medical era, human health is experiencing numerous challenges, particularly
the human malignancies. Therefore, the therapeutic arsenal for these malignancies is to be …
the human malignancies. Therefore, the therapeutic arsenal for these malignancies is to be …
In silico identification of novel SARS-COV-2 2′-O-methyltransferase (nsp16) inhibitors: structure-based virtual screening, molecular dynamics simulation and MM …
The novel coronavirus disease COVID-19, caused by the virus SARS CoV-2, has exerted a
significant unprecedented economic and medical crisis, in addition to its impact on the daily …
significant unprecedented economic and medical crisis, in addition to its impact on the daily …
Identification of a New Potential SARS-COV-2 RNA-Dependent RNA Polymerase Inhibitor via Combining Fragment-Based Drug Design, Docking, Molecular …
The world has recently been struck by the SARS-Cov-2 pandemic, a situation that people
have never before experienced. Infections are increasing without reaching a peak. The …
have never before experienced. Infections are increasing without reaching a peak. The …
Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS
Multi-targeted anticancer drugs are in focus as a promising research topic. A new series of
benzothiazoles hybridized with pyrimidine moiety was designed and synthesized using the …
benzothiazoles hybridized with pyrimidine moiety was designed and synthesized using the …
Toward the identification of potential α-ketoamide covalent inhibitors for SARS-CoV-2 main protease: Fragment-based drug design and MM-PBSA calculations
Since December 2019, the world has been facing the outbreak of the SARS-CoV-2
pandemic that has infected more than 149 million and killed 3.1 million people by 27 April …
pandemic that has infected more than 149 million and killed 3.1 million people by 27 April …
Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal
The current investigation aimed for loading fenticonazole nitrate (FTN), an antifungal agent
with low aqueous solubility, into trans-novasomes (TNs) for management of tinea corporis …
with low aqueous solubility, into trans-novasomes (TNs) for management of tinea corporis …
Salmon sperm DNA binding study to cabozantinib, a tyrosine kinase inhibitor: Multi-spectroscopic and molecular docking approaches
In the current work, the binding interaction of cabozantinib with salmon sperm DNA (SS-
DNA) was studied under simulated physiological conditions (pH 7.4) using fluorescence …
DNA) was studied under simulated physiological conditions (pH 7.4) using fluorescence …
Atorvastatin loaded lecithin-coated zein nanoparticles based thermogel for the intra-articular management of osteoarthritis: in-silico, in-vitro, and in-vivo studies
Purpose Up-to-date literature offers limited data about utilizing atorvastatin calcium (ATV) as
a promising chondroprotective agent in osteoarthritis (OA). So, this study aims to develop a …
a promising chondroprotective agent in osteoarthritis (OA). So, this study aims to develop a …
Identifying different mutation sites leading to resistance to the direct-acting antiviral (DAA) sofosbuvir in hepatitis C virus patients from Egypt
The hepatitis C virus (HCV) is a major global health challenge and a leading cause of
morbidity and mortality. Many direct-acting antivirals (DAAs) target essential …
morbidity and mortality. Many direct-acting antivirals (DAAs) target essential …
Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors
MA El Hassab, WM Eldehna… - Journal of Enzyme …, 2022 - Taylor & Francis
On account of its crucial role in the virus life cycle, SARS-COV-2 NSP13 helicase enzyme
was exploited as a promising target to identify a novel potential inhibitor using multi-stage …
was exploited as a promising target to identify a novel potential inhibitor using multi-stage …