Centriolar satellites comprise cytoplasmic granules that are located around the centrosome.
Their molecular identification was first reported more than a quarter of a century ago. These …

Polo-like kinases (Plks) are critical regulatory molecules during the cell cycle process. This
family has five members: Plk1, 2, 3, 4, and 5. Plk4 has been identified as a master regulator …

Hundreds of E3 ligases play a critical role in recognizing specific substrates for modification
by ubiquitin (Ub). Separating genuine targets of E3s from E3-interactors remains a …

Autophagy maintains cellular health and homeostasis during stress by delivering cytosolic
material captured by autophagosomes to lysosomes for degradation. Autophagosome …

To elucidate the role of centriolar satellites in ciliogenesis, we deleted the gene encoding
the PCM1 protein, an integral component of satellites. PCM1 null human cells show marked …

Dysregulation of Notch signaling has been implicated in cellular transformation and
tumorigenesis in a variety of cancers while potential roles of MIB1, an E3 ubiquitin ligase …

Centriolar satellites are non-membranous cytoplasmic granules that concentrate in the
vicinity of the centrosome, the major microtubule-organizing centre (MTOC) in animal cells …

Adenoviruses (AdVs) cause respiratory, ocular, and gastrointestinal tract infection and
inflammation in immunocompetent people and life-threatening disease upon …

Introduction: Polo like kinase (PLK) is known to play a pivotal role in various cell cycle
processes to perpetuate proper division and growth of the cells. Polo like kinase-4 (PLK4) is …

Abstract Polo-like kinase 4 (PLK4), a highly conserved serine/threonine kinase, masterfully
regulates centriole duplication in a spatiotemporal manner to ensure the fidelity of …