In order to understand the functioning of organisms on the molecular level, we need to know
which genes are expressed, when and where in the organism, and to which extent. The …

The newly emerging field of computational cell biology requires software tools that address
the needs of a broad community of scientists. Cell biological processes are controlled by an …

There is little doubt that the central areas of traditional biochemistry (such as metabolism,
metabolic regulation and enzymology) are currently unfashionable and generally regarded …

There is no doubt that nowadays, biology benefits greatly from mathematics. In particular,
cellular biology is, besides population dynamics, a field where tech niques of mathematical …

MOTIVATION: Genome sequencing projects and further systematic functional analyses of
complete gene sets are producing an unprecedented mass of molecular information for a …

MOTIVATION: The simulation of biochemical kinetic systems is a powerful approach that can
be used for:(i) checking the consistency of a postulated model with a set of experimental …

Biochemical networks in single cells can display large fluctuations in molecule numbers,
making mesoscopic approaches necessary for correct system descriptions. We present a …

Today, in silico studies and trial simulations already complement experimental approaches
in pharmaceutical R&D and have become indispensable tools for decision making and …

Study of the cell will never be complete unless its dynamic behavior is understood. The
complex behavior of the cell cannot be determined or predicted unless a computer model of …

Being a relatively new addition to the 'omics' field, metabolomics is still evolving its own
computational infrastructure and assessing its own computational needs. Due to its strong …