Analytical and biochemical perspectives of protein O-GlcNAcylation
Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …
unique monosaccharide modification discovered in the early 1980s. With the technological …
Demystifying the O-GlcNAc code: a systems view
Post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc), a process
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …
FOXA1 O-GlcNAcylation–mediated transcriptional switch governs metastasis capacity in breast cancer
Y Liu, K Yu, X Kong, K Zhang, L Wang, N Zhang… - Science …, 2023 - science.org
FOXA1, a transcription factor involved in epigenetic reprogramming, is crucial for breast
cancer progression. However, the mechanisms by which FOXA1 achieves its oncogenic …
cancer progression. However, the mechanisms by which FOXA1 achieves its oncogenic …
[HTML][HTML] Growing and dividing: how O-GlcNAcylation leads the way
Cell cycle errors can lead to mutations, chromosomal instability, or death; thus, the precise
control of cell cycle progression is essential for viability. The nutrient-sensing post …
control of cell cycle progression is essential for viability. The nutrient-sensing post …
Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass
EO Akinbiyi, LK Abramowitz, BL Bauer, MSK Stoll… - Scientific Reports, 2021 - nature.com
O-GlcNAcylation is a prevalent form of glycosylation that regulates proteins within the
cytosol, nucleus, and mitochondria. The O-GlcNAc modification can affect protein cellular …
cytosol, nucleus, and mitochondria. The O-GlcNAc modification can affect protein cellular …
Mechanistic roles for altered O-GlcNAcylation in neurodegenerative disorders
Neurodegenerative diseases such as Alzheimer's and Parkinson's remain highly prevalent
and incurable disorders. A major challenge in fully understanding and combating the …
and incurable disorders. A major challenge in fully understanding and combating the …
O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer's disease by inhibiting necroptosis
O-GlcNAcylation (O-linked β-N-acetylglucosaminylation) is notably decreased in Alzheimer's
disease (AD) brain. Necroptosis is activated in AD brain and is positively correlated with …
disease (AD) brain. Necroptosis is activated in AD brain and is positively correlated with …
Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O‐GlcNAcylation of cyclin‐dependent‐like kinase 5
J Wu, Z Tan, H Li, M Lin, Y Jiang, L Liang… - Journal of Pineal …, 2021 - Wiley Online Library
Melatonin helps to maintain circadian rhythm, exerts anticancer activity, and plays key roles
in regulation of glucose homeostasis and energy metabolism. Glycosylation, a form of …
in regulation of glucose homeostasis and energy metabolism. Glycosylation, a form of …
The intra-mitochondrial O-GlcNAcylation system rapidly modulates OXPHOS function and ROS release in the heart
J Dontaine, A Bouali, F Daussin, L Bultot… - Communications …, 2022 - nature.com
Protein O-GlcNAcylation is increasingly recognized as an important cellular regulatory
mechanism, in multiple organs including the heart. However, the mechanisms leading to O …
mechanism, in multiple organs including the heart. However, the mechanisms leading to O …
Real talk: the inter-play between the mTOR, AMPK, and hexosamine biosynthetic pathways in cell signaling
GK Cork, J Thompson, C Slawson - Frontiers in endocrinology, 2018 - frontiersin.org
O-linked N-acetylglucosamine, better known as O-GlcNAc, is a sugar post-translational
modification participating in a diverse range of cell functions. Disruptions in the cycling of O …
modification participating in a diverse range of cell functions. Disruptions in the cycling of O …