Kaposi sarcoma (KS) gained public attention as an AIDS-defining malignancy; its
appearance on the skin was a highly stigmatizing sign of HIV infection during the height of …

Abstract Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–
Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I …

Kaposi sarcoma (KS) herpesvirus (KSHV), also known as human herpesvirus 8, is the
causal agent of KS but is also pathogenetically related to several lymphoproliferative …

The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system …

The expression of pattern-recognition receptors (PRRs) by immune and tissue cells provides
the host with the ability to detect and respond to infection by viruses and other …

A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …

Advances in innate immunity over the past decade have revealed distinct classes of pattern
recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular …

Interferon regulatory factors (IRFs) are a family of homologous proteins that regulate the
transcription of interferons (IFNs) and IFN-induced gene expression. As such they are …

Members of the interferon-regulatory factor (IRF) proteins family were originally identified as
transcriptional regulators of the Type I interferon system. Thanks to consistent advances …